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ZM-447439
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| Z125121-50mg | 331771-20-1 | 询价 |
| Z125121-5mg | 331771-20-1 | 询价 |
| Z125121-10mg | 331771-20-1 | 询价 |
产品介绍
- 分子式 C29H31N5O4
- 分子量513.59
属性
| 溶解性 | Soluble in DMSO (25 mg/ml), methanol, water (<1 mg/ml) at 25 °C, ethanol (48 mg/ml) at 25 °C, DMF (~20 mg/ml), and DMSO:PBS (1:1, pH 7.2) (~0.5 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A selective inhibitor of ARK-1, ARK-2, and ARK-3. |
| 产品介绍 | ZM 447439是一种选择性的，ATP竞争性Aurora A和Aurora B抑制剂，IC50分别为110 nM和130 nM，作用于Aurora A/B比作用于MEK1， Src， Lck选择性高8倍，对CDK1/2/4， Plk1， Chk1等几乎没有作用效果。 |
| 备注 | ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect againstCDK1/2/4, |
| 生化机理 | ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000 nM, Ki=100nM), ARK-2 (B) (IC50= 50 nM, Ki= 0.36 nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound specifically interacts at the ATP-binding site and at the adjacent cleft, found only in aurora kinases. In the presence of Z-M447439, chromosome alignment, segregation, and cytokinesis during mitosis are unsuccessful. Studies show that ZM-447439 can override the spindle assembly checkpoint and accelerate meiosis I in mouse oocytes. |
| 别名 | ZM447439; N-[4-[[6-甲氧基-7-[3-(4-吗啉基)丙氧基]-4-喹唑啉基]氨基]苯基]苯甲酰胺;ZM447439;ZM 447439;N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide |
ZM-447439信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于ZM-447439报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途