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Y-27632 dihydrochloride
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| Y129399-100mg | 129830-38-2 | 询价 |
| Y129399-50mg | 129830-38-2 | 询价 |
| Y129399-5mg | 129830-38-2 | 询价 |
| Y129399-10mg | 129830-38-2 | 询价 |
产品介绍
- 分子式 C14H21N3O·2HCl
- 分子量320.26
- MDL号 MFCD03490488
- PubChem编号 24277699
属性
| 溶解性 | Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A cell permeable inhibitor of ROCK-1 and ROCK-2 |
| 产品介绍 | Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2. |
| 合法信息 | Sold under license from Mitsubishi Pharma Corporation |
| 备注 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits >200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| 生化机理 |
Y-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively. |
| 别名 | (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor;(1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride;ROCK Inhibitor |
Y-27632 dihydrochloride信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Y-27632 dihydrochloride报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途