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VAL-083
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
V125883-5mg | 23261-20-3 | 询价 |
V125883-10mg | 23261-20-3 | 询价 |
V125883-50mg | 23261-20-3 | 询价 |
- 分子式 C6H10O4
- 分子量146.14
属性
溶解性 | 25°C: DMSO |
存贮条件 | 储存温度-20°C |
描述
生化机理 |
Description: IC50 Value: 5uM (inhibit U251, SF188, T98G cell growth in monolayer after 72h) VAL-083 surpasses temozolomide (TMZ) activity and inhibits cancer stem cells (CSCs) providing a new potential treatment option for glioblastoma multiforme (GBM). VAL-083 inhibited U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis [1]. in vitro: VAL-083 inhibited U251 and SF188 cell growth in monolayer and as neurospheres better than TMZ and caused apoptosis after 72 hr. In the colony formation assay, VAL-083 (5 uM) suppressed SF188 growth by about 95%. T98G cells are classically TMZ-resistant and express MGMT, but VAL-083 inhibited their growth in monolayer after 72 hr in a dose-dependent manner (IC50, 5 uM). VAL-083 also inhibited the growth of CSCs (BT74, GBM4, and GBM8) by 80-100% in neurosphere self-renewal assays. Conversely, there was minimal effect on normal human neural stem cells [1]. in vivo: N/A Clinical trial: Safety Study of VAL-083 in Pat |
别名 | ;Dianhydrodulcitol;Dianhydrogalactitol;VAL083 |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途