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Temozolomide
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T127425-500mg | 85622-93-1 | 询价 |
| T127425-250mg | 85622-93-1 | 询价 |
| T127425-100g | 85622-93-1 | 询价 |
| T127425-5g | 85622-93-1 | 询价 |
| T127425-1g | 85622-93-1 | 询价 |
| T127425-25g | 85622-93-1 | 询价 |
产品介绍
- 分子式 C6H6N6O2
- 分子量194.15
- MDL号 MFCD00866492
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (5 mg/ml at 25 °C), DMSO (39 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | An apoptosis inducer which causes arrest at the G2/M cell cycle checkpoint. |
| 产品介绍 | Temozolomide是一种DNA损伤诱导剂。 |
| 生化机理 | Temozolomide is an antitumor, antiangiogenic compound that has been shown to work by alkylating DNA, typically through addition of a methyl group to guanine in genomic DNA. The efficacy of this compound is dependent on its ability to methylate the DNA, thus triggering apoptosis; however, some cells are able to repair this damage via the enzymes O-6-methylguanine-DNA methyltransferase (MGMT). As a enzyme. Research has also been conducted to determine whether MGMT inhibitors such as O-6-benzylguanine might help to increase the efficacy of temozolomide. Furthermore, temozolomide has been implicated in causing arrest at the G2/M cell cycle checkpoint, which might also play a role in its cytotoxicity. |
| 别名 | 替莫唑胺;3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺;8-氨基甲酰基-3-甲基咪唑[5,1-d]并-1,2,3,5-四氮嗪-4-(3H)-酮;4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬-2,7,9-三烯-9-甲酰胺; 3-甲基-4-氧代-8-咪唑并[5,1-d][1,2,3,5]四嗪甲酰胺;NSC 362856; CCRG 81045; TZM;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide |
Temozolomide信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Temozolomide报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途