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Minisite
细胞凋亡
NVP-LCQ195
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
N127100-50mg | 902156-99-4 | 询价 |
N127100-5mg | 902156-99-4 | 询价 |
N127100-25mg | 902156-99-4 | 询价 |
产品介绍
- 分子式 C17H19Cl2N5O4S
- 分子量460.33
属性
溶解性 | DMSO |
存贮条件 | 储存温度-20°C |
描述
产品介绍 | NVP-LCQ195 (AT9311; LCQ195)是CDK杂环类抑制剂,对CDK1,CDK2,CDK3和CDK5的IC50为1-42 nM。 |
生化机理 | NVP-LCQ195 (AT9311; LCQ195) is a small molecule heterocyclic compound which inhibits CDK1, CDK2 and CDK5, as well as CDK3 and CDK9. Cell cycle regulators, such as cyclin-dependent kinases (CDKs), are appealing targets for multiple myeloma (MM) therapy given the increased proliferative rates of tumour cells in advanced versus early stages of MM. NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-μmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. |
别名 | LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311;4-(2,6-二氯苯甲酰基氨基)-1H-吡唑-3-羧酸 N-[1-(甲基磺酰基)哌啶-4-基]酰胺;LCQ-195;AT-9311;NVP LCQ195;LCQ 195;AT9311;AT 9311;4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid N-[1-(methylsulfonyl)piperidin-4-yl]amide |
NVP-LCQ195信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于NVP-LCQ195报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途