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Alvespimycin
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A125535-100mg | 467214-20-6 | 询价 |
| A125535-25mg | 467214-20-6 | 询价 |
产品介绍
属性
| 溶解性 | Soluble in water, ethanol (10 mg/mL), and DMSO (>25 mg/mL). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A synthetic Geldanamycin derivative and inhibitor of Hsp90. |
| 产品介绍 | Alvespimycin (17-DMAG; KOS-1022; NSC 707545)是水溶性HSP90抑制剂，IC50为62 nM。 |
| 生化机理 | 17-DMAG, 17-dimethylaminoethylamino-17-demethoxygeldanamycin, is a synthetic derivative of the antibiotic Geldanamycin with lower hepatotoxicity than the parent antibiotic and higher potency and availability than the similar derivative 17-AAG .17-DMAG is described to bind and inhibit the activity of Hsp90 (heat shock protein 90), a cellular chaperone that is over expressed in many cancers, and which participates in folding of proteins found in multiple signal transduction pathways. |
| 别名 | 17-DMAG; KOS-1022; NSC 707545;阿螺旋霉素; 17-[2-(二甲基氨基)乙基氨基]-17-去甲氧基格尔德霉素;17-DMAG; KOS-1022; NSC 707545;17-Dimethylaminoethylamino-17-demethoxygeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin |
Alvespimycin信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Alvespimycin报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途