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Barasertib (AZD1152-HQPA)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A127799-50mg | 722544-51-6 | 询价 |
| A127799-10mg | 722544-51-6 | 询价 |
| A127799-250mg | 722544-51-6 | 询价 |
产品介绍
- 分子式 C26H30FN7O3
- 分子量507.56
- MDL号 MFCD10687152
属性
| 沸点 | 796.7° C at 760 mmHg |
| 折光率 | 1.68 |
| 溶解性 | DMSO ≥100mg/mL Water ≥100mg/mL Ethanol ≥2.8mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A highly selective ARK-2 inhibitor |
| 产品介绍 | AZD1152-HQPA是AZD-1152的活性代谢物，AZD1152-HQPA (Barasertib)是Aurora B 高选择性抑制剂，IC50为0.37 nM，比对Aurora A的抑制性高100倍。 |
| 备注 | AZD1152-HQPA (Barasertib) is a highly selective Aurora B inhibitor with IC50 of 0.37 nM, ~100 fold more selective for Aurora B over Aurora A. |
| 生化机理 | AZD1152-HQPA is the active metabolite of AZD-1152, a potent selective Aurora Kinase B inhibitor. AZD1152 is 50-fold selective for Aurora kinase B over Aurora kinase C and over 1000-fold selective for Aurora kinase B over Aurora Kinase A. (IC50s: aurora-A, 1,369 nmol/L; aurora-B, 0.36 nmol/L; aurora-C, 17.0 nmol/L). It is converted in plasma to the active form AZD1152-HQPA, which has been shown to have antineoplastic activity in a variety of animal models and human cancer cell lines. |
| 别名 | AZD1152; AZD 1152; 5-((7-(3-(乙基(2-羟基乙基)氨基)丙氧基)-4-喹唑啉)氨基)-N-(3-氟苯基)-1H-吡唑-3-乙酰胺;;Barasertib;5-((7-(3-(ethyl(2-hydroxyethyl)amino)propoxy)-4-quinazolinyl)amino)-n-(3-fluorophenyl)-1h-pyrazole-3-acetamide；3-[[7-[3-[Ethyl(2-hydroxyethyl)amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-1H-pyrazole-5-acetamide |
Barasertib (AZD1152-HQPA)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Barasertib (AZD1152-HQPA)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途