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Vinblastine
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| V127032-20mg | 865-21-4 | 询价 |
| V127032-10mg | 865-21-4 | 询价 |
| V127032-250mg | 865-21-4 | 询价 |
| V127032-50mg | 865-21-4 | 询价 |
产品介绍
属性
| 溶解性 | 25°C: DMSO 67 mg/mL; Water <1 mg/mL; Ethanol 7 mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | Vinblastine抑制微管形成，抑制nAChR活性，IC50为8.9 μM。 |
| 备注 | Vinblastine inhibits microtubule formation and supresses nAChR activity with IC50 of 8.9 μM. |
| 生化机理 | Vinblastine does not interfere with phrenic nerve stimulation of rat diaphragm musculature in concentrations up to 200 microM. However, in relatively high doses, vinblastine (10-200 microM) produces an increase in baseline tension of diaphragm muscle. This effect is concentration related (EC50, approximately 88 microM), reversible, and independent of phrenic nerve stimulation. The elevation in baseline tension is unaffected by nAChR blockade via d-tubocurarine, but is dependent upon the presence of extracellular calcium. In human Burkitt lymphoma CA46 cells, vinblastine (IC50 values, 1.0 nM). It binds tubulin, thereby inhibiting the assembly of microtubules.It is used to treat certain kinds of cancer, including Hodgkin |
| 别名 | Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth;长春花碱;Vincaleukoblastine, Velban, Velsar;1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid,4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-,meth |
Vinblastine信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Vinblastine报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途