普通会员
诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
细胞凋亡
NVP-AUY922
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| N126962-5mg | 747412-49-3 | 询底价 |
| N126962-10mg | 747412-49-3 | 询底价 |
| N126962-50mg | 747412-49-3 | 询底价 |
| N126962-25mg | 747412-49-3 | 询底价 |
| N126962-100mg | 747412-49-3 | 询底价 |
产品介绍
- 分子式 C26H31N3O5
- 分子量465.54
属性
| 溶解性 | Soluble in DMSO (100 mg/mL), ethanol (100 mg/mL), and water (very poorly soluble). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A highly potent HSP90 inhibitor to HSP90α and HSP90β |
| 产品介绍 | Luminespib (AUY-922, NVP-AUY922)是一种高效的HSP90抑制剂，其对HSP90α/β的IC50为13 nM /21 nM，对HSP90家族成员GRP94和TRAP-1具有稍弱的作用，与任何HSP90配体均可紧密结合。Phase 2。 |
| 备注 | AUY922 (NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 1/2. |
| 生化机理 | NVP-AUY922 inhibits proliferation of various human cancer cell lines in vitro, with an average GI50 of 9 nM. The IC50 values of NVP-AUY922 fall in the range of 2 to 40 nM in these gastric cancer cell lines. IC50 value for the BEAS-2B cells is 28.49 nM. Treatment with NVP-AUY922 does not influence the expression of Hsp90, but expression of HSP70 gets elevated by NVP-AUY922 treatment. NVP-AUY922 increases the binding of HSP70 to Hsp90. NVP-AUY922 causes p23 dissociation from the Hsp90 complex and can then recruit HSP70 to the Hsp90 complex. Meanwhile, treatment with NVP-AUY922 causes decreased expression of HER-2 in NCI-N87 cells. NVP-AUY922 treatment results in binding of Hsp90 to client proteins and setting them up as targets for degradation by the proteasome.NVP-AUY922 can influence cell growth by affecting mutiple signaling pathways. |
| 别名 | 5-[2,4-二羟基-5-异丙基苯基]-N-乙基-4-[4-(4-吗啉基甲基)苯基]-3-异恶唑甲酰胺;AUY922;VER-52296;NVP-AUY 922;AUY-922;VER 52296;VER52296;5-[2,4-Dihydroxy-5-isopropylphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide |
NVP-AUY922信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于NVP-AUY922报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途