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Irinotecan HCl Trihydrate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| I129860-100mg | 136572-09-3 | 询价 |
| I129860-1g | 136572-09-3 | 询价 |
| I129860-250mg | 136572-09-3 | 询价 |
| I129860-500mg | 136572-09-3 | 询价 |
产品介绍
- 分子式 C33H38N4O6·HCl·3H2O
- 分子量677.18
- Beilstein号
- EC号
- MDL号 MFCD01765731
- PubChem编号
属性
| 沸点 | 257°C |
| 旋光率 | +22.0 to +26.0 deg(C=1, methanol) |
| 敏感性 | 对热敏感 |
| 溶解性 |
|
| 存贮条件 | 储存温度2-8℃ |
描述
| 应用 | An inhibitor of Topo I. |
| 产品介绍 | Irinotecan HCl Trihydrate通过抑制Topoisomerase 1（拓扑异构酶1）而防止DNA解链。 |
| 备注 | Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. |
| 生化机理 | Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line. |
| 别名 | 三水盐酸伊立替康;盐酸伊立替康三水合物;伊立替康盐酸盐三水合物;PNU-101440E;CPT-11 Trihydrate;Irinotecan Hydrochloride Trihydrate;(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinolin-9-yl ester monohydrochloride trihydrate Irinotecan monohydrochloride trihydrate |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途