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GW9662
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| G125880-10mg | 22978-25-2 | 询价 |
| G125880-250mg | 22978-25-2 | 询价 |
| G125880-50mg | 22978-25-2 | 询价 |
产品介绍
- 分子式 C13H9ClN2O3
- 分子量276.68
- Beilstein号
- EC号 MFCD01215270
- MDL号 MFCD01215270
- PubChem编号 24883187
属性
| 溶解性 | Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1:2 DMF : PBS (PH=7.2) (~0.5 mg/ml). Insoluble in water. |
| 存贮条件 | 储存温度2-8°C |
描述
| 应用 | A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist. |
| 产品介绍 | GW9662是一种选择性PPAR拮抗剂，作用于PPARγ，IC50为3.3 nM，作用于PPARγ比作用于PPARα和PPARδ选择性强100到1000倍。 |
| 备注 | GW9662 is a selective PPAR antagonist for PPARγ with IC50 of 3.3 nM, with at least 100 to 1000-fold functional selectivity in cells with PPARγversus PPARα and PPARδ. |
| 生化机理 | GW 9662 is a selective, irreversible, and effective peroxisome proliferator activated receptor-γ (PPARγ) antagonist. PPARγ research demonstrates that GW 9662 covalently modifies Cys(285) and does not affect transcription of full-length PPARα and PPARδ. GW 9662 has been shown to block Rosiglitazone mediated activation of PPARγ, and improve growth inhibition induced by Rosiglitazone in breast tumor cell research. Additionally, reports indicate that GW 9662 blocks the protective activity of lipopolysaccharide, LPS, and acts as an agonist for the farnesoid X receptor (FXR) and pregnane X receptor (PXR) nuclear receptors. |
| 别名 | 2-氯-5-硝基苯甲酰苯胺;2-氯-5-硝基-N-苯基苯酰胺;GW 9662;GW-9662;2-Chloro-5-nitro-N-phenylbenzamide |
GW9662信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于GW9662报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途