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NU7026
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| N129741-10mg | 154447-35-5 | 询价 |
| N129741-50mg | 154447-35-5 | 询价 |
产品介绍
- 分子式 C17H15NO3
- 分子量281.31
- MDL号 MFCD06798345
属性
| 溶解性 | Soluble in DMSO (3 mg/ml) at 60 °C, methanol (700 μg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | An antiproliferative agent, and inhibitor of DNA-PK. |
| 产品介绍 | NU7026是一种有效的DNA-PK抑制剂，IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，抑制ATM和ATR活性。 |
| 备注 | NU7026 is a potent DNA-PK inhibitor with IC50 of 0.23 μM, 60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR. |
| 生化机理 | DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair. |
| 别名 | NU 7026; 2-(4-吗啉基)-4H-萘并[1,2-b]吡喃-4-酮;LY293646; NU-7026; LY 293646; LY-293646;LY293646; NU-7026; LY 293646; LY-293646; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one;DNA-PK Inhibitor II |
NU7026信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于NU7026报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途