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Minisite
动植物激素
GW9508
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
G126253-250mg | 885101-89-3 | 询价 |
G126253-50mg | 885101-89-3 | 询价 |
G126253-10mg | 885101-89-3 | 询价 |
产品介绍
-
分子式 C22H21NO3
- 分子量347.41
- Beilstein号
- EC号
- MDL号 MFCD09753282
- PubChem编号
属性
溶解性 | Soluble in ethanol (100 mM), DMSO (40 mg/ml), DMF (~15 mg/ml), and Ethanol : PBS (1:1) (~0.5 mg/ml) |
存贮条件 | 储存温度2-8°C |
描述
应用 | An aminophenylpropanoate agonist at the GRP40/FFA1 receptor. |
产品介绍 | GW9508是一种有效的,选择性FFA1(GPR40)激动剂,pEC50为7.32,比作用于GPR120选择性高100倍,以葡萄糖敏感性方式刺激胰岛素的分泌。 |
备注 | GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner. |
生化机理 | GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ~50 nM) with reduced activity towards family members GRP120 (EC50 ~3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. GW 9508 has been shown to induce GPR40-dependent Ca2+ mobilization in HEK 293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. |
别名 | 4-[[(3-苯氧基苯基)甲基]氨基]苯丙酸;GW 9508;GW-9508;3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid; GPR40 Agonist;4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid |
GW9508信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于GW9508报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途