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其它表观遗传学和基因调控试剂
Entinostat (MS-275)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| E125068-50mg | 209783-80-2 | 询价 |
| E125068-10mg | 209783-80-2 | 询价 |
| E125068-100mg | 209783-80-2 | 询价 |
| E125068-250mg | 209783-80-2 | 询价 |
产品介绍
- 分子式 C21H20N4O3
- 分子量376.41
- MDL号 MFCD03453552
属性
| 溶解性 | Soluble in methanol, DMSO (~30 mg/ml), DMF (~30 mg/ml), ethanol (~2 mg/ml), 1:1 solution of DMSO:PBS(PH7.2) (~0.5 mg/ml), and water (<1 mg/ml) at 25 °C. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An HDAC inhibitor shown to inhibit angiogenesis and metastasis. |
| 产品介绍 | Entinostat (MS-275)对HDAC1和HDAC3抑制作用强于与HDACs 4， 6， 8，和10，IC50分别为0.51 μM和1.7 μM。 |
| 备注 | Entinostat (MS-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, compared with HDACs 4, 6, 8, and 10. Phase 1/2. |
| 生化机理 | MS-275 is an inhibitor of HDAC (histone deacetylase) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM). However, MS-275 does not inhibit HDAC8 (IC50 > 100 μM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in vivo. Recent studies suggest that MS-275 may be particularly useful as an antineoplastic agent when combined with other drugs, like adriamycin, inhibitors of poly (ADP-ribose) polymerase (PARP), or inhibitors of heat shock protein 90 (Hsp90). |
| 别名 | SNDX-275;恩替诺特; N-[[4-[[(2-氨基苯基)氨基]甲酰]苯基]甲基]氨基甲酸 3-吡啶基甲基酯;MS-275; SNDX-275; MS 275; SNDX 275;A HDAC1 and HDAC3 inhibitor;3-pyridinylmethyl [[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]carbamate; N-(2-Aminophenyl)-4-[N-(pyridine-3ylmethoxycarbonyl)aminomethyl]benzamide |
Entinostat (MS-275)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Entinostat (MS-275)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途