诚信认证:
工商注册信息已核实!
CI-994
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
C126432-10mg | 112522-64-2 | 询价 |
C126432-250mg | 112522-64-2 | 询价 |
C126432-50mg | 112522-64-2 | 询价 |
- 分子式 C15H15N3O2
- 分子量269.3
- MDL号 MFCD00866266
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
应用 | An HDAC1, HDAC3, HDAC6, and HDAC8 inhibitor |
产品介绍 | CI-994 (Tacedinaline)是抗癌化合物,能抑制HDAC1,IC50为0.57 μM,能促使细胞周期停滞于G1期。 |
备注 | CI-994 (Tacedinaline) is an anti-cancer drug which inhibits HDAC1 with IC50 of 0.57 μM and causes G1 cell cycle arrest. Phase 3. |
生化机理 |
Description: IC50 Value: 0.57 uM (For HDAC1,MTT assay) CI-994 (N-acetyldinaline) is a novel oral compound with a wide spectrum of antitumor activity in preclinical models, in vitro and in vivo. The mechanism of action may involve inhibition of histone deacetylation and cell cycle arrest[1]. in vitro: Different CI-994 concentrations were tested, ranging from 0.01 to 160 microM at 24, 48, and 72 h of treatment inA-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma) ,with MTT assay. A concentration-dependent cell survival inhibition was observed, with an IC50 at 80 microM. The effect of CI-994, as demonstrated by recovery experiments, was cytostatic and seemed to be superimposable in both cell lines. Cytofluorimetric analysis to assess cell cycle perturbation and apoptosis was performed after 24 h of treatment, indicating a cell block with concomitant increase at G0/G1 phase, a reduction at S phase level at 20, 40, 80, and 160 microM, and apoptosis at the higher conce |
别名 | PD-123654;4-乙酰氨基-N-(2-氨基苯基)苯甲酰胺;乙酰地那林;Acetyldinaline;Tacedinaline;PD 123654;Goe 5549;CI 994;CI994; 4-Acetylamino-N-(2′-aminophenyl)benzamide ; |
CI-994信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于CI-994报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途