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其它表观遗传学和基因调控试剂
CUDC-101
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| C127191-25mg | 1012054-59-9 | 询价 |
| C127191-10mg | 1012054-59-9 | 询价 |
| C127191-250mg | 1012054-59-9 | 询价 |
| C127191-50mg | 1012054-59-9 | 询价 |
| C127191-100mg | 1012054-59-9 | 询价 |
产品介绍
- 分子式 C24H26N4O4
- 分子量434.49
属性
| 溶解性 | DMSO ≥40mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent inhibitor of HDACs and receptor tyrosine kinases |
| 产品介绍 | CUDC-101是HDAC，EGFR和HER2抑制剂，IC50分别为4.4，2.4和15.7 nM。 |
| 备注 | CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. |
| 生化机理 | CUDC-101 inhibits the erlotinib-resistant EGFR mutant T790M although its effects are incomplete with an Amax of ~60% of peak enzyme activity after inhibition. CUDC-101 treatment increases the acetylation of histone H3 and H4, as well as the acetylation of non-histone substrates of HDAC such as p53 and α-tubulin, in a dose-dependant manner in various cancer cell lines. CUDC-101 also suppresses HER3 expression, Met amplification, and AKT reactivation in tumor cells. |
| 别名 | 7-((4-(3-乙炔基苯基氨基)-7-甲氧基喹唑啉-6-基)氧基)-N-羟基庚酰胺;;CUDC101;CUDC 101;7-((4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-n-hydroxyheptanamide |
CUDC-101信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于CUDC-101报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途