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其它表观遗传学和基因调控试剂
Trichostatin A
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129665-5mg | 58880-19-6 | 询底价 |
| T129665-10mg | 58880-19-6 | 询底价 |
| T129665-50mg | 58880-19-6 | 询底价 |
产品介绍
- 分子式 C17H22N2O3
- 分子量302.37
- MDL号 MFCD03848392
- PubChem编号 24900542
属性
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent and non-competitive reversible inhibitor of HDAC. |
| 产品介绍 | Trichostatin A (TSA)是一种HDAC抑制剂，IC50为1.8 nM左右，HDAC8是HDAC家族中唯一不受TSA影响的成员。 |
| 备注 | Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA. Phase 3. |
| 生化机理 | Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle. |
| 别名 | TSA;曲古抑菌素 A;曲古柳菌素A ;TSA; R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
Trichostatin A信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Trichostatin A报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途