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其它表观遗传学和基因调控试剂
Panobinostat (LBH589)
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| P125167-50mg | 404950-80-7 | 询底价 |
| P125167-10mg | 404950-80-7 | 询底价 |
产品介绍
属性
| 溶解性 | Soluble in DMSO (70 mg/ml), methanol, water (<1.2 mg/ml), DMF (~50 mg/ml), and ethanol (~3.3 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | An HDAC inhibitor reported to inhibit human multiple myeloma cell lines. |
| 产品介绍 | Panobinostat (LBH589)是一种新型的，广谱的HDAC抑制剂，IC50为5 nM。Phase 3。 |
| 备注 | Panobinostat (LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM. Phase 3. |
| 生化机理 | Panobinostat (LBH589) is a HDAC (histone deactylase) inhibitor of research interest for multiple diseases such as multiple myeloma. The deacetylation of histones is associated with transcriptional silencing. Panobinostat was reported to inhibit several human multiple myeloma cell lines with and IC50 ≥ 20nM. Panobinostat was also reported to induce expression of DNA damage response genes and induce apoptosis in Ph- acute lymphoblastic leukemia cells. |
| 别名 | 帕比司他;LBH-589; LBH589; NVP-LBH589;(E)-N-Hydroxy-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylamide;N-Hydroxy-3-[4-[2-(2-methyl-1H-indol-3-yl)ethylaminomethyl]phenyl]-2(E)-propenamide |
Panobinostat (LBH589)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Panobinostat (LBH589)报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途