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G蛋白偶联受体&G蛋白
AM251
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129844-100mg | 183232-66-8 | 询价 |
| A129844-25mg | 183232-66-8 | 询价 |
| A129844-5mg | 183232-66-8 | 询价 |
产品介绍
- 分子式 C22H21Cl2IN4O
- 分子量555.24
- Beilstein号
- EC号 MFCD01861181
- MDL号
- PubChem编号
属性
| 熔点 | 196-198 °C |
| 溶解性 | Soluble in DMSO (~10 mg/ml), ethanol (~10 mg/ml), DMF (~10 mg/ml), and 1:3 DMSO:PBS (pH 7.2) (~14 mg/ml). Insoluble in water |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 |
An inverse agonist of the CB1 receptor; AM251, a CB1 cannabinoid receptor antagonist, has been used in a study to determine its interaction with hippocampal neurons to enhance spatial memory in mice. |
| 产品介绍 | AM251是大麻素CB1受体拮抗剂，IC50为700 nM，在体内与小鼠脑CB1受体结合。 |
| 备注 | AM251 block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. |
| 生化机理 | AM-251 is a 123I radioisotope and potent CB1 receptor antagonist derivative of the CB1 cannabinoid receptor inverse agonist SR141716A, presenting a radioprobe for in vivo binding studies at the CB1 receptor with a higher affinity (Ki = 7.49 nM) for CB1 than the parent compound (Ki = 11.5 nM). AM-251 has been employed in competitive binding studies to identify CB1 affinity of different cannabimimetic agonists in vivo. Characterization of AM-251-CB1 association with SPECT (single photon emission computed tomography) has been described. AM-251 is also a potent activator of the GPR55 receptor. |
| 别名 | 1-(2,4-二氯苯基)-5-(4-碘苯基)-4-甲基-N-1-哌啶基-1H-吡唑-3-甲酰胺;AM 251;AM-251;1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide;AM 251;AM-251 |
AM251信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于AM251报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途