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G蛋白偶联受体&G蛋白
Ki16425
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| K126742-1mg | 355025-24-0 | 询价 |
| K126742-25mg | 355025-24-0 | 询价 |
| K126742-2mg | 355025-24-0 | 询价 |
| K126742-5mg | 355025-24-0 | 询价 |
产品介绍
属性
| 沸点 | 623.7° C at 760 mmHg |
| 熔点 | 59.5-60.5° C |
| 折光率 | 1.63 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.3500 |
描述
| 应用 | A competitive inhibitor of EDG-2, EDG-4, and EDG-7. |
| 产品介绍 | Ki16425是竞争性的可逆的LPA拮抗剂，对LPA1，LPA2和LPA3的Ki分别为0.34 μM，6.5 μM和0.93 μM，而对LPA4，LPA5和LPA6无活性。 |
| 生化机理 | Kil6425 preferentially inhibits LPA1- and LPA3-mediated responses but has only a moderate effect on LPA2. Ki16425 inhibits the LPA-induced Ca(2+) response in THP-1 cells, 3T3 fibroblasts, and A431 cells, but had only a marginal effect in PC-12 cells and HL-60 cells, which means that Ki16425 seems to be a useful tool for evaluating the involvement of specific LPA receptors in the short-term response to LPA. Ki16425 inhibits long-term DNA synthesis and cell migration as induced by LPA in Swiss 3T3 fibroblasts . Ki16425 reduces the LPA-induced activation of p42/p44 mitogen activated protein kinase (MAPK), while acting as a weak stimulator of p42/p44 MAPK on its own, properties typical of a protean agonist. Ki16425 also significantly reduces the NGF-induced stimulation of p42/p44 MAPK and inhibited NGF-stimulated neurite outgrowth in PC-12 cells. |
| 别名 | Ki-16425; Ki 16425; 3-[[[4-[4-[[[1-(2-氯苯基)乙氧基]羰基]氨基]-3-甲基-5-异恶唑基]苯基]甲基]硫基]丙酸;Ki-16425; Ki 16425; 3-[[[4-[4-[[[1-(2-Chlorophenyl)ethoxy]carbonyl]amino]-3-methyl-5-isoxazolyl]phenyl]methyl]thio]-propanoic acid |
Ki16425信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Ki16425报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途