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G蛋白偶联受体&G蛋白
Dapagliflozin
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| D126800-10mg | 461432-26-8 | 询价 |
| D126800-1g | 461432-26-8 | 询价 |
| D126800-250mg | 461432-26-8 | 询价 |
| D126800-50mg | 461432-26-8 | 询价 |
产品介绍
属性
| 溶解性 | Soluble in ethanol (~30 mg/ml), DMSO (82 mg/ml at 25 °C), DMF (~30 mg/ml), ethanol:PBS(pH7.2)(1:1) (~0.5 mg/ml), and methanol. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A SGLT-2 inhibitor |
| 产品介绍 | Dapagliflozin是一种有效的，选择性的hSGLT2抑制剂，EC50为1.1 nM，比作用于hSGLT1选择性高1200倍。Phase 4。 |
| 备注 | Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 3. |
| 生化机理 | Dapagliflozin, a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) is in development for the treatment of type 2 diabetes mellitus (T2DM). Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. From Wikipedia. |
| 别名 | BMS-512148;(1S)-1,5-脱水-1-C-[4-氯-3-[(4-乙氧基苯基)甲基]苯基]-D-葡萄糖醇;达格列净;达格列嗪;BMS-512148;BMS512148;BMS 512148;(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol |
Dapagliflozin信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Dapagliflozin报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途