诚信认证:
工商注册信息已核实!
![](https://img.antpedia.com/cbook/dist_templates/0/images/icon04.png)
![](https://cbook.antpedia.com/attachments/design/6751/1577268752-5396.png)
Toremifene
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
T126260-25mg | 89778-26-7 | 询价 |
T126260-100mg | 89778-26-7 | 询价 |
- 分子式 C26H28ClNO
- 分子量405.96
属性
溶解性 | 25°C: DMSO 120mg/mL ;Water <1mg/mL; Ethanol <1mg/mL |
存贮条件 | 储存温度-20°C |
描述
生化机理 |
IC50 Value: 1±0.3μM. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT in men with prostate cancer [1]. in vitro: The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[2]. in vivo: The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[2]. Clinical trial: Prostate cancer diagnosis among men with isolated high-grade intraepithelial neoplasia enrolled onto a 3-year prospective phase III clinical trial of oral toremifene[3]. |
Toremifene信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Toremifene报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途