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Salirasib
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| S124985-100mg | 162520-00-5 | 询价 |
| S124985-25mg | 162520-00-5 | 询价 |
| S124985-200mg | 162520-00-5 | 询价 |
属性
| 溶解性 | DMSO <20mg/mL; Ethanol <20mg/mL; DMF <20mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | Salirasib是一种有效的竞争性prenylated protein methyltransferase (PPMTase)抑制剂， Ki为2.6 μM，其抑制Ras甲基化。Phase 2。 |
| 生化机理 |
Salirasib is a salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Salirasib binds to a cell membrane anchor protein thereby selectively blocking a cascade of biochemical signals known as the Ras signaling pathway. The Ras pathway plays an important role in tumor growth and is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast. Up to 90% of human pancreatic cancers are driven by aberrant oncogenic Ras signaling. |
| 别名 | ;S-Farnesylthiosalicylic acid; Farnesyl Thiosalicylic Acid; FTS |
Salirasib信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Salirasib报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途