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G蛋白偶联受体&G蛋白
ONO-AE3-208
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| O125509-25mg | 402473-54-5 | 询价 |
| O125509-5mg | 402473-54-5 | 询价 |
| O125509-10mg | 402473-54-5 | 询价 |
| O125509-50mg | 402473-54-5 | 询价 |
产品介绍
- 分子式 C24H21FN2O3
- 分子量404.43
属性
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | ONO-AE3-208(AE 3-208)是EP4拮抗剂，能抑制前列腺癌细胞侵袭，迁移和转移。 |
| 生化机理 |
EP4 over-expressing LNCaP was established, and their cell invasiveness was compared with the control LNCaP (LNCaP/mock). The in vitro cell proliferation, invasion, and migration of these cells were examined under different concentrations of ONO-AE3-208. An in vivo bone metastatic mouse model was constructed by inoculating luciferase expressing PC3 cells into left ventricle of nude mice. Their bone metastasis was observed by bioluminescent imaging with or without ONO-AE3-208 administration. The EP4 mRNA expression levels were higher in PC3 than in LNCaP, and EP4 over-expression of LNCaP cells enhanced their cell invasiveness. Arachidonic acid caused dose-dependent dilation of the attached Af-Art (from 8.6 ± 1.2 to 15.3 ± 0.7 μm; P<0.001; n=6), and this effect was blocked by ONO-AE3-208 (10(-7) mol/L). |
| 别名 | AE 3-208;ONO AE3 208； 4-氰基-2-[[2-(4-氟-1-萘基)-1-氧代丙基]氨基]苯基丁酸;AE 3-208;ONO AE3 208；4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoic acid |
ONO-AE3-208信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于ONO-AE3-208报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途