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G蛋白偶联受体&G蛋白
NPS-2143
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
N125903-25mg | 284035-33-2 | 询底价 |
N125903-5mg | 284035-33-2 | 询底价 |
N125903-100mg | 284035-33-2 | 询底价 |
产品介绍
- 分子式 C24H25ClN2O2
- 分子量408.93
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | NPS-2143(SB 262470A)是选择性的Ca(2+)受体拮抗剂,IC50为43 nM。 |
生化机理 | NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH [1]. The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH . |
别名 | NPS 2143; SB 262470A; NPS2143;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈;NPS 2143; SB 262470A; NPS2143;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile |
NPS-2143信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于NPS-2143报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途