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AM1241

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
A129838-10mg 444912-48-5 询价
A129838-1mg 444912-48-5 询价
A129838-25mg 444912-48-5 询价
A129838-50mg 444912-48-5 询价
A129838-5mg 444912-48-5 询价
产品介绍

  • 分子式 C22H22IN3O3
  • 分子量503.33
  • Beilstein号
  • EC号 MFCD11045986
  • MDL号
  • PubChem编号

属性

溶解性
  • DMSO 101 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
    • 存贮条件 储存温度-20°C

    描述

    应用 (R,S)-AM1241, a selective CB2 cannabinoid receptor agonist, has been used to study neuropathic pain in animal models
    产品介绍 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
    备注 AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
    生化机理 AM-1241 is a protean agonist of CB2 based on the different effect observed in various assays (calcium influx, extracellular signal-regulated kinase (ERK) phosphorylatin and cAMP measurement)) and on the switch from neutral antagonism to agonism in the cAMP assay when forskolin concentration is lowered. In [3H]CP 55,940 competition binding assays, AM-1241 displays high affinity at the human CB2 receptor with a Ki value of about 7 nM, whereas its affinity at the human CB1 receptor is more than 80-fold weaker, using membrane preparations from stable HEK and CHO cell lines expressing the recombinant human CB2 and CB1 receptors, respectively.
    别名 ((R,S)-AM 1241; (R,S)-3-(2-碘-5-硝基苯甲酰)-1-(1-甲基-2-哌啶甲基)-1H-吲哚;(R,S)-AM1241; (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole

    AM1241信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于AM1241报价、型号、参数等信息，欢迎来电或留言咨询。

    注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途