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S3I-201
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| S129625-10mg | 501919-59-1 | 询价 |
| S129625-5mg | 501919-59-1 | 询价 |
| S129625-50mg | 501919-59-1 | 询价 |
- 分子式 C16H15NO7S
- 分子量365.36
- MDL号 MFCD09907564
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | S3I-201 |
| 备注 | S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM, and low activity towards STAT1 and STAT5. |
| 生化机理 |
NSC 74859 (S3I-201) inhibits Stat3-Stat3 complex formation and Stat3 DNA-binding (IC50 =86 ±33μM) and transcriptional activities. Furthermore, S31-201 inhibits growth and induces apoptosis preferentially in tumor cells that contain persistently activated Stat3. NSC 74859 (S3I-201) inhibits the expression of the Stat3-regulated genes encoding cyclin D1, BcI-xL, and survivin and inhibits the growth of human breast tumors in vivo. Therefore the antitumor activity of S31-201 is mediated in part through inhibition of aberrant Stat3 activation and provide the proof-of-concept for the potential clinical use of Stat3 inhibitors such as NSC 74859 (S31-201) in tumors harboring aberrant Stat3. |
| 别名 | 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid;2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid |
S3I-201信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于S3I-201报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途