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AZD1480
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A126326-100mg | 935666-88-9 | 询价 |
| A126326-1mg | 935666-88-9 | 询价 |
| A126326-25mg | 935666-88-9 | 询价 |
| A126326-5mg | 935666-88-9 | 询价 |
产品介绍
属性
| 沸点 | ~575.2 °C at 760 mmHg |
| 熔点 | 213.39 °C |
| 折光率 | 1.70 |
| 溶解性 | DMSO ≥68mg/mL Water <1.2mg/mL Ethanol ≥4.7mg/mL |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.5000 |
描述
| 应用 | An inhibitor of JAK2 |
| 产品介绍 | AZD1480是ATP竞争性JAK2抑制剂，IC50为0.26 nM，对JAK1抑制性较弱。 |
| 备注 | AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1/2. |
| 生化机理 | AZD1480 demonstrated significant immunoregulatory effects by downregulating T-helper 2 cytokines and chemokines, including IL-13 and thymus- and activation-regulated chemokine, and the surface expression of the immunosuppressive programmed death ligands 1 and 2. Higher concentrations of AZD1480 (5μ) induced G2/M arrest and cell death by inhibiting Aurora kinases |
| 别名 | AZD1480;AZD 1480; 5-氯-N2-((1S)-1-(5-氟-2-嘧啶基)乙基)-N4-(5-甲基-1H-吡唑-3-基)-2,4-嘧啶二胺;;AZD1480;AZD 1480；5-chloro-n2-((1s)-1-(5-fluoro-2-pyrimidinyl)ethyl)-n4-(5-methyl-1h-pyrazol-3-yl)-2,4-pyrimidinediamine；(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine |
AZD1480信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于AZD1480报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途