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离子通道
Flunarizine 2HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| F129526-100g | 30484-77-6 | 询价 |
| F129526-5g | 30484-77-6 | 询价 |
| F129526-1g | 30484-77-6 | 询价 |
| F129526-500g | 30484-77-6 | 询价 |
| F129526-25g | 30484-77-6 | 询价 |
产品介绍
- 分子式 C26H26F2N2·2HCl
- 分子量477.42
- Beilstein号 4284243
- EC号 250-216-6
- MDL号 MFCD00058198
- PubChem编号 24277835
属性
| 溶解性 | Soluble in DMSO (25 mg/mL), ethanol (5 mg/mL warm), methanol, 0.1N HCI, and chloroform/methanol (9:1) (50 mg/mL). Insoluble in water, and dilute aqueous base.. |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A calcium channel protein inhibitor. |
| 产品介绍 | Flunarizine 2HCl是一种二氢盐酸盐，抑制钙离子通道，Ki为68 nM。 |
| 备注 | Flunarizine dihydrochloride is a dihydrochloride salt form which is a calcium channel blocker with a Ki of 68 nM. |
| 生化机理 | Flunarizine ? 2HCl, a calcium channel protein inhibitor and antagonist, has been shown to inhibit contraction of isolated murine caudal artery preparations. Mechanistic studies suggest that this compound inhibits prostaglandin-induced and Serotonin ? HCl induced components of the contraction via reduction in the amounts of TXB2 (Thromboxane B2) and ALK-1, and an increase in production of HETE. Experiments on rabbit sino-atrial nodes and isolated guinea-pig papillary muscles have reported that Flunarizine ? 2HCl depressed the slow action potentials of K+-depolarized papillary muscle. Additionally, studies indicate that Flunarizine ? 2HCl selectively suppresses Ca2+ influx through the cell membrane of sino-atrial nodes. |
| 别名 | 盐酸氟桂利嗪; (E)-1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)-哌嗪二盐酸盐;1-[双(4-氟苯基)甲基]-4-(3-苯基-2-丙烯基)哌嗪 二盐酸盐;Sibelium;Flunarizine dihydrochloride;1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride |
Flunarizine 2HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Flunarizine 2HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途