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Ivacaftor (VX-770)

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询价
产品参数
货号 CAS号 操作
V127056-10mg 873054-44-5 询价
V127056-250mg 873054-44-5 询价
V127056-100mg 873054-44-5 询价
V127056-50mg 873054-44-5 询价
V127056-500mg 873054-44-5 询价
V127056-1g 873054-44-5 询价
V127056-5mg 873054-44-5 询价
产品介绍

  • 分子式 C24H28N2O3
  • 分子量392.49

属性

溶解性
  • DMSO 78 mg/mL
  • Water <1 mg/mL
  • Ethanol <1 mg/mL
    • 存贮条件 储存温度-20°C

    描述

    应用 Is a CFTR activator
    产品介绍 Ivacaftor (VX-770)是一种囊性纤维化跨膜传导调节器(CFTR)的增强剂，靶向作用于G551D-CFTR和F508del-CFTR，EC50分别为100 nM和25 nM。
    备注 Ivacaftor (VX-770, Kalydeco) is a potentiator of CFTR targeting G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively.
    生化机理 Ivacaftor is a CFTR activator (IC50 of 43 ± 38 nM). In some cells Ivacaftor was shown to increase CFTR channel open probability in the F508del processing and the G551D gating mutations. In cultured human CF bronchial epithelia (HBE) expressing the F551D gating mutation on one allele and F508del processing mutation on the other allele, Ivacaftor was shown to increase Cl- secretion by about 10-fold, to about 50% of that observed in HBE isolated from individuals without CF, in addition, Ivacaftor reduced excessive Na+ and fluid absorption preventing dehydration of the apical surface and increased cilia beating in these epithelial cultures.
    别名 VX 770; N-(2,4-二叔丁基-5-羟基苯基)-1,4-二氢-4-氧代-3-喹啉甲酰胺;VX770; Ivacaftor; VX 770;Kalydeco;N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

    Ivacaftor (VX-770)信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Ivacaftor (VX-770)报价、型号、参数等信息，欢迎来电或留言咨询。

    注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途