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TRAM-34
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| T129575-100mg | 289905-88-0 | 询价 |
| T129575-25mg | 289905-88-0 | 询价 |
| T129575-50mg | 289905-88-0 | 询价 |
| T129575-5mg | 289905-88-0 | 询价 |
产品介绍
- 分子式 C22H17ClN2
- 分子量344.84
- Beilstein号
- EC号 MFCD09842562
- MDL号 MFCD09842562
- PubChem编号
属性
| 溶解性 | Soluble in DMSO (10 mg/ml at 40°C), ethanol (6 mg/ml at 40°C), and DMF (>25 mg/ml), dichloromethane, ethyl acetate, and methanol. Insoluble in water. |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 产品介绍 | TRAM-34 has been shown to be an inhibitor of cloned and native IK1 channels in human T lymphocytes. These K+ channels have been implicated in over-proliferation of cells. Inhibition of IK1 channels has been demonstrated to modulate cell proliferation depending on the concentration of TRAM-34. Mechanistic studies have shown that TRAM-34 may cause a halt in cell growth at the G0/G1 phase. |
| 备注 | TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. |
| 别名 | 1-[(2-氯苯基)二苯甲基]-1H-吡唑;1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole |
TRAM-34信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于TRAM-34报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途