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Vonoprazan Fumarate (TAK-438)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
T125625-100mg | 1260141-27-2 | 询价 |
T125625-1g | 1260141-27-2 | 询价 |
T125625-25mg | 1260141-27-2 | 询价 |
T125625-5mg | 1260141-27-2 | 询价 |
产品介绍
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
产品介绍 | TAK-438是钾竞争性的酸阻滞剂,能可逆的抑制H+/K+-ATPase,IC50为19 nM(pH 6.5)。 |
备注 | TAK-438 is a novel P-CAB (potassium-competitive acid blocker) that reversibly inhibits H+/K+, ATPase with IC50 of 19 nM (pH 6.5), controls gastric acid secretion. Phase 3. |
生化机理 | TAK-438 is a pyrrole derivative with a chemical structure that is completely different from the P-CABs developed to date. TAK-438 inhibits gastric H+, K+-ATPase activity in a concentration-dependent manner. Under neutral conditions (pH 7.5), the inhibitory activity of TAK-438 is almost the same as that under weakly acidic conditions (pH 6.5). TAK-438 does not inhibit Na+, K+-ATPase activity even at concentration 500 times higher than their IC50 values against gastric H+,K+-ATPase activity. TAK-438 inhibits gastric H+, K+-ATPase in a K+-competitive manner with Ki of 3 nM. |
别名 | TAK-438;5-(2-氟苯基)-N-甲基-1-(3-吡啶基磺酰基)-1H-吡咯-3-甲胺富马酸盐;TAK 438;TAK438;5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate |
Vonoprazan Fumarate (TAK-438)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于Vonoprazan Fumarate (TAK-438)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途