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PF-04971729
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| P127306-10mg | 1210344-57-2 | 询价 |
| P127306-50mg | 1210344-57-2 | 询价 |
| P127306-5mg | 1210344-57-2 | 询价 |
属性
| 溶解性 | DMSO |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | PF-04971729(Ertugliflozin)是钠离子依赖的葡萄糖协同转运蛋白2（SGLT2）抑制剂。 |
| 生化机理 |
PF-04971729, a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2, is currently in phase 2 trials for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated uptake of [14C]metformin by PF-04971729 also were very weak (IC50 900μM).The disposition of PF-04971729, an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [14C]-PF-04971729 to healthy human subjects. The absorption of PF-04971729 in humans was rapid with a Tmax at ~ 1.0 h. Of the total radioactivity excreted in feces and urine, unchanged PF-04971729 collectively accounted for ~ 35.3% of the dose, suggestive of moderate metabolic elimination in humans. |
| 别名 | 1,6-脱水-1-C-[4-氯-3-[(4-乙氧基苯基)甲基]苯基]-5-C-(羟基甲基)-beta-L-艾杜糖;PF04971729;PF 04971729;Ertugliflozin;PF04971729;PF 04971729;1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose |
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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途