诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
离子通道
ML133 HCl
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M129577-50mg | 1222781-70-5 | 询价 |
| M129577-250mg | 1222781-70-5 | 询价 |
| M129577-5mg | 1222781-70-5 | 询价 |
| M129577-10mg | 1222781-70-5 | 询价 |
| M129577-1g | 1222781-70-5 | 询价 |
产品介绍
- 分子式 C19H19NO.HCl
- 分子量313.82
- MDL号 MFCD20921521
属性
| 溶解性 | DMSO 63 mg/mL Water <1 mg/mL Ethanol 6 mg/mL |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters. |
| 产品介绍 | ML133 HCl是一种选择性钾离子通道抑制剂，作用于Kir2.1， IC50为1.8 μM (pH 7.4)和290 nM (pH 8.5)，对Kir1.1没有作用效果，对Kir4.1和Kir7.1具有微弱的作用活性。 |
| 备注 | ML133 is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. |
| 生化机理 | ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters. |
| 别名 | (4-甲氧基苄基)(1-萘基甲基)胺盐酸盐;1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride; CID 781301 hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride; SID 85281105 hydrochloride; VU0404943-1 hydrchloride |
ML133 HCl信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于ML133 HCl报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途