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盐酸马尼地平
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
M129521-25mg | 89226-75-5 | 询价 |
M129521-1g | 89226-75-5 | 询价 |
M129521-50mg | 89226-75-5 | 询价 |
M129521-100mg | 89226-75-5 | 询价 |
M129521-500mg | 89226-75-5 | 询价 |
- 分子式 C35H38N4O6·2HCl
- 分子量683.62
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | Manidipine 2HCl is a HCl salt form of Manidipine, which is a calcium channel blocker with IC50 of 2.6 nM, used clinically as an antihypertensive. Phase 4. |
生化机理 |
Manidipine dihydrochloride is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. Manidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. |
别名 | 1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸-2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基酯二盐酸盐;2-[4-(二苯基甲基)-1-哌嗪基]乙基甲基-1,4-二氢-2,6-二甲基-4-(3-硝基苯基)-3,5-吡啶二羧酸酯二盐酸盐;1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester Dihydrochloride;2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate Dihydrochloride |
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途