诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
离子通道
盐酸氨溴索
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129556-100g | 23828-92-4,18683-91-5 | 询价 |
| A129556-25g | 23828-92-4,18683-91-5 | 询价 |
| A129556-5g | 23828-92-4,18683-91-5 | 询价 |
产品介绍
- 分子式 C13H18Br2N2O·HCl
- 分子量414.56
- Beilstein号
- EC号 245-899-2
- MDL号 MFCD00078932
- PubChem编号 24891499
属性
| 熔点 | 235°C(dec.)(lit.) |
| 溶解性 | Soluble in methanol, water (~5 mg/ml), ethanol (~5 mg/ml), and DMSO (50 mM). Insoluble in ether. |
描述
| 应用 | An expectorant antioxidant and antiinflammatory agent |
| 产品介绍 | Ambroxol HCl是有效的神经性钠离子通道抑制剂，抑制抗TTX的钠离子电流，相位性阻滞，IC50为22.5 μM，抑制对TTX敏感的钠离子电流，IC50为100 μM。Phase 3。 |
| 备注 | AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. |
| 生化机理 | Ambroxol hydrochloride is a small molecule expectorant and mucolytic agent with antioxidant and antiinflammatory effects. Ambroxol stimulates the secretion of surfactant which decreases mucus adhesion to the bronchial lining and produces expectorant effects. The antioxidant effects of Ambroxol are well demonstrated, where lipid peroxidation initiated by t-butyl hydroperoxide or doxorubicin is suppressed in the presence Ambroxol, and scavenging of hydroxyl radicals and cellular superoxide radical anions is also observed. Ambroxol produces antiinflammatory effects by blocking the expression of proinflammatory messengers, inhibiting the release of histamine from mast cells and the generation of cytokines and interleukins. Ambroxol hydrochloride is an inhibitor of Sodium Channel Protein. |
| 别名 | 氨溴索 盐酸盐;2-氨基-3,5-二溴-N-(反式-4-羟基环己基)苄胺;Ambroxol Hydrochloride;trans-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol Hydrochloride;2-Amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl)benzylamine |
盐酸氨溴索信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于盐酸氨溴索报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途