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Dabrafenib
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| D127289-100mg | 1195765-45-7 | 询价 |
| D127289-1g | 1195765-45-7 | 询价 |
| D127289-25mg | 1195765-45-7 | 询价 |
| D127289-500mg | 1195765-45-7 | 询价 |
| D127289-5mg | 1195765-45-7 | 询价 |
产品介绍
属性
| 沸点 | ~653.7 °C at 760 mmHg |
| 折光率 | 1.63 |
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
描述
| 应用 | A potent and selective inhibitor of Raf-B protein kinase carrying V600E mutation |
| 产品介绍 | Dabrafenib (达拉菲尼; GSK2118436)是高活性BRAFV600特异性抑制剂，IC50为0.8 nM，比对野生型B-Raf和c-Raf的抑制性高4倍和6倍。 |
| 备注 | Dabrafenib (GSK2118436) is a mutant BRAFV600 specific inhibitor with IC50 of 0.8 nM, with 4- and 6-fold less potency against B-Raf(wt) and c-Raf, respectively. Phase 3. |
| 生化机理 |
Dabrafenib is an orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. |
| 别名 | 达拉菲尼;GSK-2118436A; GSK-2118436; GSK2118436A; GSK2118436A; GSK 2118436; GSK 2118436; N-(3-(5-(2-氨基-4-嘧啶基)-2-(叔丁基)-4-噻唑基)-2-氟苯基)-2,6-二氟苯磺酰胺;;GSK-2118436A;GSK-2118436;GSK2118436A;GSK2118436A;GSK 2118436;GSK 2118436;n-(3-(5-(2-amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide |
Dabrafenib信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Dabrafenib报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途