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ZM 336372
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| Z129624-50mg | 208260-29-1 | 询价 |
| Z129624-5mg | 208260-29-1 | 询价 |
| Z129624-10mg | 208260-29-1 | 询价 |
产品介绍
- 分子式 C23H23N3O3
- 分子量389.45
- MDL号 MFCD02683971
属性
| 敏感性 | 对光敏感 |
| 溶解性 | Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25 °C), and ethanol (2 mg/ml at 25 °C). |
| 存贮条件 | 储存温度 2-8°C |
描述
| 应用 | A potent and selective Raf-1 inhibitor. |
| 产品介绍 | ZM 336372是一种有效的，选择性的c-Raf抑制剂，IC50为70 nM，比作用于B-RAF选择性高10倍，对PKA/B/C， AMPK， p70S6等没有抑制作用。 |
| 备注 | ZM 336372 is a potent and selective c-Raf inhibitor with IC50 of 70 nM, 10-fold selectivity over B-RAF, no inhibition to PKA/B/C, AMPK, p70S6, etc. |
| 生化机理 | ZM 336372 is a reversible, selective inhibitor of the protein kinase Raf-1 (IC50 = 70nM). Although ZM 336372 weakly inhibits Raf-B, it is 10 fold more potent against Raf-1 and so is considered more selective towards this kinase. ZM 336372 inhibits Raf-1 by competing with ATP to bind to the protein. Alternate studies suggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β (GSK-3β) through phosphorylation of GSK-3&beta at Ser 9. In addition, ZM 336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM 336372 can also act as an agonist towards Raf-1, activating the MAPK pathway, which can be suppressed after activation by Raf-1 itself, using a novel feedback loop in which activation is always followed by inactivation. ZM 336372 is an inhibitor of p38 α and p38 β. |
| 别名 | ZM336372; ZM-336372; 3-(二甲基氨基)-N-[3-[(4-羟基苯甲酰基)氨基]-4-甲基苯基]苯甲酰胺;3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide;ZM336372; ZM-336372 |
ZM 336372信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于ZM 336372报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途