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U0126-EtOH
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| U127670-25mg | 1173097-76-1 | 询价 |
| U127670-500mg | 1173097-76-1 | 询价 |
| U127670-100mg | 1173097-76-1 | 询价 |
产品介绍
- 分子式 C18H16N6S2.C2H6O
- 分子量426.56
属性
| 溶解性 | DMSO ≥83mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 | U0126-EtOH(U-0126)是MEK1和2选择性抑制剂，IC50分别为70nM和60nM，对ΔN3-S218E/S222D MEK的亲和力比PD098059强100倍。 |
| 备注 | U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD098059. |
| 生化机理 | U0126-EtOH functionally antagonizes AP- 1 transcriptional activity and blocks the production of a variety of cytokines and metalloproteinases involved in the inflammatory response. U0126-EtOH inhibits T cell proliferation in response to antigenic stimulation or cross-linked anti-CD3 plus anti-CD28 Abs without effect on IL-2-induced proliferation by down-regulating IL-2 mRNA levels . A recent study shows that U0126-EtOH antagonizes resveratrol-induced apoptosis in castration-resistant human prostate cancer C4-2 cells, inhibits mitochondrial function and shifts cells to aerobic glycolysis independently of MEK . |
| 别名 | U 0126;U-0126 ;2,3-双[氨基[(2-氨基苯基)硫]亚甲基]丁二腈乙醇盐;U 0126;U-0126;2,3-Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile ethanol salt |
U0126-EtOH信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于U0126-EtOH报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途