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SP600125
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| S125267-100mg | 129-56-6 | 询价 |
| S125267-5g | 129-56-6 | 询价 |
| S125267-25mg | 129-56-6 | 询价 |
| S125267-1g | 129-56-6 | 询价 |
| S125267-500mg | 129-56-6 | 询价 |
产品介绍
- 分子式 C14H8N2O
- 分子量220.233
- MDL号 MFCD00022289
属性
| 熔点 | 283° C |
| 溶解性 | DMSO ≥42mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A potent, selective and reversible inhibitor of JNK1, JNK-2, and JNK-3 |
| 产品介绍 | SP600125是泛JNK抑制剂，对JNK1，JNK2和JNK3的IC50分别为40 nM，40 nM和90 nM，比对MKK4和MKK3，MKK6，PKB，PKCα的抑制性高10倍和超过25倍。 |
| 备注 | SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selec |
| 生化机理 |
SP600125 is selective inhibitor of c-Jun N-terminal kinase (JNK). SP600125 competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 μM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. |
| 别名 | 吡唑蒽酮; 蒽并[1,9-cd]吡唑-6(2H)-酮;SP 600125;SP-600125;1,9-Pyrazoloanthrone;Anthra[1,9-cd]pyrazol-6(2H)-one;JNK Inhibitor II |
SP600125信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于SP600125报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途