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PD98059

品牌 厂商性质 产地 货期
阿拉丁 生产商 上海 现货

询底价
产品参数
货号 CAS号 操作
P126620-10mg 167869-21-8 询底价
P126620-50mg 167869-21-8 询底价
产品介绍

属性

敏感性 对热敏感
溶解性 Soluble in DMSO (6.5 mg/ml), anhydrous DMSO (25 mg/ml), ethanol (0.6 mg/ml), dichloromethane, methanol, DMF (~20 mg/ml), and DMSO:PBS (1:9 pH7.2) (~0.25 mg/ml). Insoluble in 2-hydroxypropyl-β-cyclodextrin, water, and dilute aqueous acid.
存贮条件 储存温度-20°C

描述

应用 A selective inhibitor of MEK and blocker of MAP
产品介绍 PD98059是一种非ATP竞争性的MEK抑制剂，无细胞试验中IC50为2 μM，特异性抑制MEK-1介导的MAPK激活；不直接抑制ERK1或ERK2。
备注 PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2.
生化机理 PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 μM) produced by nerve growth factor. It has been shown to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.
别名 PD 98059;PD-98059;2-(2-氨基-3-甲氧苯基)色酮; 2-(2-氨基-3-甲氧苯基)-4H-1-苯并吡喃-4-酮;PD 98059; PD-98059;PD 98,059; 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one;2-(2-Amino-3-methoxyphenyl)chromone;2′-Amino-3′-methoxyflavone

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途