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GW501516
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
| 货号 | CAS号 | 操作 |
|---|---|---|
| G129772-250mg | 317318-70-0 | 询底价 |
| G129772-25mg | 317318-70-0 | 询底价 |
| G129772-50mg | 317318-70-0 | 询底价 |
| G129772-5mg | 317318-70-0 | 询底价 |
- 分子式 C21H18F3NO3S2
- 分子量453.50
- Beilstein号 18515150
- EC号 MFCD09033000
- MDL号 MFCD09033000
属性
| 溶解性 |
|
| 存贮条件 | 储存温度-20°C |
描述
| 产品介绍 |
{2- |
| 备注 | GW501516 is a potent and highly selective PPARβ/δ agonist, with EC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ. Phase 4. |
| 生化机理 |
GW501516 (GW1516 or GSK-516) is a drug that acts as a PPARδ modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation. It has been proposed as a potential treatment for obesity and related conditions, especially when used in conjunction with a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal studies. |
| 别名 | GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid;GW1516, GSK-516, GW-501516;2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy)acetic acid |
GW501516信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于GW501516报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途