诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
药物分子
Voriconazole
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| V129745-500mg | 137234-62-9 | 询价 |
| V129745-5g | 137234-62-9 | 询价 |
| V129745-50mg | 137234-62-9 | 询价 |
| V129745-250mg | 137234-62-9 | 询价 |
| V129745-1g | 137234-62-9 | 询价 |
产品介绍
- 分子式 C16H14F3N5O
- 分子量349.31
- Beilstein号
- EC号
- MDL号 MFCD00905717
- PubChem编号
属性
| 沸点 | ~508.6° C at 760 mmHg |
| 熔点 | 128-134° C |
| 旋光率 | -58.0 to -62.0 deg(C=1, MeOH) |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 存贮条件 | 储存温度-20°C |
| 密度 | 1.4000 |
描述
| 应用 | An antifungal CYP2C9 inhibitor |
| 产品介绍 | Voriconazole (伏立康唑; UK-109496) 是第二代三唑类抗真菌化合物，可作用于严重的真菌感染。 |
| 备注 | Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. |
| 生化机理 | Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes. Posaconazole is a highly potent broadspectrum antifungal drug. It blocks the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase resulting in accumulation of methylated sterol precursors. In contrast to other antifungal azoles, posaconazole has been reported not to induce the efflux pump mechanism. Posaconazole was able to produce a parasitological cure in a mouse model of the chronic stage of Chagas disease |
| 别名 | 伏立康唑; (2R,3S)-2-(2,4-二氟苯基)-3-(5-氟嘧啶-4-基)-1-(1H-1,2,4-三唑-1-基)-2-丁醇;Vfend;UK-109496; 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
Voriconazole信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Voriconazole报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途