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Minisite
药物分子
WY-14643 (Pirinixic Acid)
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
货号 | CAS号 | 操作 |
---|---|---|
W129766-5g | 50892-23-4 | 询底价 |
W129766-1g | 50892-23-4 | 询底价 |
W129766-250mg | 50892-23-4 | 询底价 |
产品介绍
- 分子量323.80
属性
溶解性 | Soluble in DMSO (65 mg/ml at 25 °C), ethanol (52 mg/ml at 25 °C), DMF (~16.5 mg/ml), PBS (pH 7.2, ~0.04 mg/ml), and water (<1 mg/ml at 25 °C). |
描述
应用 | A highly potent PPARα agonist |
产品介绍 | WY-14643 (Pirinixic Acid)是一种有效的过氧化物酶体增殖子和PPARα激活剂,EC50为1.5 μM。 |
备注 | WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM. |
生化机理 | WY 14643 is a highly potent PPARα agonist. Peroxisome proliferator-activated receptors (PPARs) α, β, and γ are hormone receptors that induce the gene acyl-Coa and modulate the peroxisomal beta oxidation of fatty acids. WY 14643 has been shown to inhibit TNF-α-induced VCAM-1, and reduce TNF-α and IL-1β. Studies indicate that WY 14643 inhibits proliferation of trophoblast cells at lower concentrations than clofibric acid, and decreases the levels of S-100 β chain (S100B) protein. |
别名 | [4-氯-6-(2,3-茬胺基)-2-嘧啶硫代]乙酸;匹立尼酸;4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid;Pirinixic acid;WY 14643 |
WY-14643 (Pirinixic Acid)信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于WY-14643 (Pirinixic Acid)报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途