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药物分子
URB597
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| U126873-100mg | 546141-08-6 | 询价 |
| U126873-250mg | 546141-08-6 | 询价 |
| U126873-25mg | 546141-08-6 | 询价 |
| U126873-1g | 546141-08-6 | 询价 |
| U126873-5mg | 546141-08-6 | 询价 |
产品介绍
- 分子式 C20H22N2O3
- 分子量338.4
- MDL号 MFCD05863934
属性
| 溶解性 | Soluble in DMSO (~14 mg/ml), DMF (~10 mg/ml), 1:1 DMF:PBS(pH 7.2) (500 ug/ml), 1:2 DMSO:PBS(pH 7.2) (500 ug/ml), water (500 ug/ml) at 25 °C, and ethanol (5 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A cell permeable carbamate and potent inhibitor of fatty acid amide hydrolase (FAHH) |
| 产品介绍 | URB597是一种口服生物有效的FAAH抑制剂，IC50为4.6 nM，对其他大麻黄素相关靶点没有抑制活性。Phase 1。 |
| 备注 | URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. |
| 生化机理 | FAAH Inhibitor II is a cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of FAAH (fatty acid amide hydrolase; IC50 = 4.6 nM in brain membranes). Shown to block anandamide breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 > 30 μM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). FAAH Inhibitor II does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 > 100 μM), as well as several ion-channels and neurotransmitter transporters. |
| 别名 | KDS-4103;N-环己基氨基甲酸 3'-(氨基甲酰基)[1,1'-联苯]-3-基酯;URB597; KDS-4103;URB 597; KDS 4103; KDS4103;Cyclohexylcarbamic acid 3′-carbamoyl-biphenyl-3-yl ester |
URB597信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于URB597报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途