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药物分子
Rolipram
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| R129674-10mg | 61413-54-5 | 询底价 |
| R129674-50mg | 61413-54-5 | 询底价 |
| R129674-250mg | 61413-54-5 | 询底价 |
产品介绍
- 分子式 C16H21NO3
- 分子量275.34
- Beilstein号
- EC号 262-771-1
- MDL号 MFCD00270906
- PubChem编号 24278196
属性
| 熔点 | 130-134℃ |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in water (0.2 mg/mL ), DMSO (7.3 mg/ml ), ethanol (7 mg/ml warm), DMF (~10 mg/ml ), DMF:PBS (pH 7.2, 1:9) (~0.5 mg/ml ), and acetone (25 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 |
Rolipram has been used: 1.to investigate its effects on testicular torsion-detorsion injury. 2.to block the effects of phosphodiesterase-4 (PDE4). 3.as a component in chemically induced long-term potentiation (cLTP) induction media. |
| 产品介绍 | Rolipram enhances tissue protection, anatomical repair and functional recovery. It is used to treat asthma, arthritis, Huntington′s disease and multiple sclerosis. Rolipram inhibits injury-induced reductions in cyclic AMP, which is associated with acute central nervous system injury. It functions as an antidepressant, stimulates neurite outgrowth and axonal regeneration in the presence of myelin inhibitors. |
| 备注 | Rolipram is a PDE4-inhibitor and an anti-inflammatory agent. |
| 生化机理 | Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 μM). This compound has been shown to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and has been shown to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B. |
| 别名 | 咯利普兰;4-[3-(环戊氧基)-4-甲氧基苯基]-2-吡咯烷酮;ZK 62711;4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone |
Rolipram信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Rolipram报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途