诚信认证：
工商注册信息已核实！
快速导航
产品分类
微信二维码
Minisite
QQ号咨询
药物分子
Methotrexate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M129845-100mg | 59-05-2 | 询价 |
| M129845-1g | 59-05-2 | 询价 |
| M129845-25g | 59-05-2 | 询价 |
| M129845-500mg | 59-05-2 | 询价 |
| M129845-5g | 59-05-2 | 询价 |
产品介绍
- 分子式 C20H22N8O5
- 分子量454.44
- Beilstein号 26(3/4)3833
- EC号
- MDL号 MFCD00150847
- PubChem编号
属性
| 熔点 | 195 °C |
| 敏感性 | 对光线和湿度敏感 |
| 溶解性 | Soluble in dilute HCl or dilute alkali hydroxide solutions (i.e. 0.1M NaOH). Insoluble in plain water. |
| 存贮条件 | 储存温度 -20°C;充氩保存 |
描述
| 应用 | A cell cycle arresting agent that inhibits DHFR. |
| 产品介绍 | Methotrexate是一种抗代谢药物和抗叶酸制剂，具有抗肿瘤和免疫抑制剂活性。 |
| 备注 | Abitrexate (Methotrexate) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| 生化机理 | Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate. |
| 别名 | 甲氨蝶呤; N-[4-[[(2,4-二氨基-6-蝶啶)甲基]甲氨基]苯甲酰]-L-谷氨酸;对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸;胺甲喋呤;CL14377; WR19039; 4-氨基-N10-甲基巯基-L-谷氨酸, MTX, 氟安定, 氨甲叶酸, 氨甲喋呤;(+)-Amethopterin;Abitrexate; Rheumatrex; Amethopterin; Trexall; CL14377; WR19039;(+)-4-Amino-10-methylfolic acid; N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid |
Methotrexate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Methotrexate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途