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药物分子
Abiraterone Acetate
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| A129731-1g | 154229-18-2 | 询价 |
| A129731-5mg | 154229-18-2 | 询价 |
| A129731-100mg | 154229-18-2 | 询价 |
| A129731-250mg | 154229-18-2 | 询价 |
| A129731-25mg | 154229-18-2 | 询价 |
产品介绍
- 分子式 C26H33NO2
- 分子量391.55
属性
| 溶解性 | Soluble in methanol (sparingly), water (<1 mg/ml at 25 °C), DMF (~16 mg/ml), ethanol (28 mg/ml at 25 °C), and DMSO (~2 mg/ml). |
| 存贮条件 | 储存温度-20°C |
描述
| 应用 | A steroidal inhibitor of CYP17A1 in androgen biosynthesis |
| 产品介绍 | Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂，IC50为72 nM。 |
| 备注 | Abiraterone Acetate is an acetate salt form of Abiraterone which is a steroidal cytochrome CYP17 inhibitor with IC50 of 72 nM. |
| 生化机理 | Abiraterone acetate has been seen to be a novel steroidal inhibitor of CYP17A1(C17,20 lyase), a cytoochrome P450 complex, a rate-limiting enzyme in androgen biosynthesis resulting in inhibtion of testosterone production in both the adrenals and the testes. It has been observed to decrease the DHEA, androstenedione and testosterone. The compound has been shown to be approximately 21-24 times more potent than ketoconazole and liarozole in CYP17A1 lyase inhibition. In medicine, Abiraterone is used for treating prostate cancer. |
| 别名 | 乙酸阿比特龙酯;CB 7630, CB-7630;(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate |
Abiraterone Acetate信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于Abiraterone Acetate报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途