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SB742457
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
阿拉丁 | 生产商 | 上海 | 现货 |
货号 | CAS号 | 操作 |
---|---|---|
S127746-1mg | 607742-69-8 | 询价 |
S127746-25mg | 607742-69-8 | 询价 |
S127746-5mg | 607742-69-8 | 询价 |
- 分子式 C19H19N3O2S
- 分子量353.44
属性
溶解性 |
|
存贮条件 | 储存温度-20°C |
描述
备注 | SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2. |
生化机理 |
SB-742457, a 5-HT6 receptor antagonist, which extends into Alzheimer disease (AD) sufferers further highlights the therapeutic promise of this mechanistic approach. Alzheimer's disease is a devastating neurological condition characterized by a progressive decline in cognitive performance accompanied by behavioral and psychological syndromes, such as depression and psychosis. With the subsequent development of selective 5-HT6 receptor antagonists, preclinical studies in rodents and primates have elucidated the function of this receptor subtype in more detail. It is increasingly clear that blockade of 5-HT6 receptors leads to an improvement of cognitive performance in a wide variety of learning and memory paradigms and also results in anxiolytic and antidepressant-like activity. SB-742457 is generally safe and well tolerated and may be efficacious in Alzheimer disease. |
别名 | GSK-742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)-;GSK-742457;Quinoline, 3-(phenylsulfonyl)-8-(1-piperazinyl)- |
SB742457信息由上海阿拉丁生化科技股份有限公司为您提供,如您想了解更多关于SB742457报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途