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MRS 2578
| 品牌 | 厂商性质 | 产地 | 货期 |
|---|---|---|---|
| 阿拉丁 | 生产商 | 上海 | 现货 |
产品参数
| 货号 | CAS号 | 操作 |
|---|---|---|
| M129552-10mg | 711019-86-2 | 询价 |
| M129552-50mg | 711019-86-2 | 询价 |
产品介绍
- 分子式 C20H20N6S4
- 分子量472.67
- Beilstein号
- EC号
- MDL号 MFCD07370141
- PubChem编号 24724530
属性
| 敏感性 | 对湿度敏感 |
| 溶解性 | Soluble in DMSO (50 mM), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C). |
| 存贮条件 | 储存温度2-8°C,充氩保存 |
描述
| 应用 | A selective P2Y66 receptor antagonist. |
| 产品介绍 | MRS 2578是一种有效的P2Y6受体抑制剂，IC50为37 nM，对P2Y1， P2Y2， P2Y4和P2Y11受体的作用活性很弱。 |
| 备注 | MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. |
| 生化机理 | MRS 2578, a symmetric aryl diisothiocyanate derivative, is shown to be an inhibitor of P2Y6 receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions. P2Y receptor activation has been reported to induce phospholipase C activity. Further studies reveal that P2Y6 receptors can cause microglial phagocytosis as well as activation of P38 MAPK and expression of COX-2 in cells exposed to UVB radiation. MRS 2578 is an inhibitor of P2Y66. |
| 别名 | MRS-2578; MRS2578; N,N''-1,4-丁烷二基双[N'-(3-异异硫氰基苯基)硫脲;MRS-2578; MRS2578; 1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane;N,N''-1,4-Butanediylbis[N'-(3-isothiocyanatophenyl)thiourea |
MRS 2578信息由上海阿拉丁生化科技股份有限公司为您提供，如您想了解更多关于MRS 2578报价、型号、参数等信息，欢迎来电或留言咨询。
注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途